Yes, what about prions?

Yes, yes, IL-6: what else?

IN THIS ISSUE of the Journal of Applied Physiology, the article “Time course of changes in inflammatory markers during a 6-mo exercise intervention in sedentary middle-aged men: a randomized-controlled trial” by Thompson and colleagues (6), independent of the specific sets of results presented in the manuscript, addresses a more general question that many laboratories, in a variety of forms, ha...

Aggregating Knowledge about Prions and Amyloid

Prions, self-propagating protein structures that can be transmitted between cells and different organisms, usually consist of ordered protein aggregates. Alberti et al. (2009) now present a systematic approach for the discovery of new prions that expands the spectrum of their biological functions.

Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins

Prions are unconventional infectious agents that are composed of misfolded aggregated prion protein. Prions replicate their conformation by template-assisted conversion of the endogenous prion protein PrP. Templated conversion of soluble proteins into protein aggregates is also a hallmark of other neurodegenerative diseases. Alzheimer's disease or Parkinson's disease are not considered infectio...

Predictive coding? Yes, but from what source?

There is little doubt that predictive coding is an important mechanism in language processing-indeed, in information processing generally. However, it is less clear whether the action system is the source of such predictions during perception. Here I summarize the computational problem with motor prediction for perceptual processes and argue instead for a dual-stream model of predictive coding.

What about Memory, Consciousness, Recall, and Awareness in Anesthesia?